MECHANICS OF LUNG MICROSTRUCTURE AS A BASIS FOR LUNG MECHANICS, AND MULTISCALE-MULTIPHYSICS MODEL OF LUNG MECHANICS, AIRFLOW, BLOOD FLOW, AND DIFFUSION
This paper contains two parts – the first is related to the mechanics of lung microstructure, and the second is a formulation of a multiscale-multiphysics model of the lung. The second part considers the entire lung that relies on the mechanics of the microstructure and recently developed a multiscale composite finite element of the lung tiss...
By Miloš Kojić, Ivo Vlastelica, Boban Stojanović, Vladimir Ranković, Akira Tsuda
COMPUTATIONAL MODELING AND PARAMETRIC STUDY OF CIRCULATING TUMOR CELL (CTC) MOTION AND ATTACHMENT IN CAPILLARIES WITH PLATELET INTERACTION AND ACTIVATION
Metastasis involves the dissemination of circulating tumor cells (CTCs) from the primary tumor, their survival in the bloodstream, and eventual colonization of distant organs. Adhesive interactions with platelets, leukocytes, and endothelial cells are critical to CTC survival and extravasation. Platelet adhesion enhances CTC viability and promotes ...
By Vladimir Simić, Miljan Milošević, Aleksandar Nikolić, Shao Ning, Xuewu Liu, Fransisca Leonard, Miloš Kojić
MODELING OF PLAQUE FORMATION AND DEVELOPMENT IN ARTREAT AND TAXINOMISIS PROJECTS
This review summarizes scientific findings from three European Commission FP7 projects. The first, ARTREAT (2008-2013), focused on a multi-level, patient-specific model of artery and atherogenesis for outcome prediction, treatment decision support, and virtual hands-on training. An original method for plaque formation and development was created an...
By Nenad Filipović, Miloš Radović, Tijana Đukić, Igor Saveljić, Bogdan Milićević, Exarchos Themis, Oberdan Parodi, Dimitris Fotiadis
CONSTITUTIVE MODELS FOR SOIL AND ROCK
The paper presents the procedure of implicit stress integration for constitutive models for soil and rock. The theoretical basis of Mohr-Coulomb, Matsuoka-Nakai, Hoek-Brown and Hyperbolic soil constitutive models are presented. Stress integration was performed using the theory of incremental plasticity. The general procedure of implicit stress inte...
By Dragan Rakić, Miroslav Živković
MUSCLE MODELING IN THE FINITE ELEMENT SOLVER PAK
This paper presents the integration of muscle fatigue modeling into the finite element solver PAK, based on an extended version of Hill’s phenomenological model. While traditional muscle models focus primarily on force generation, this study incorporates fatigue dynamics to provide a more realistic representation of muscle performance over ti...
By Boban Stojanović, Miloš Kojić, Srboljub Mijailovich
HEART MODEL FOR ELECTROPHYSIOLOGY, MECHANICS AND BLOOD FLOW
Cardiovascular diseases are among the leading causes of mortality worldwide, necessitating advanced computational modeling to study their underlying mechanisms and explore potential treatments. In this paper, we present a multiphysics computational model that integrates cardiac mechanics, electrophysiology, and mass transport, implemented within th...
By Miljan Milošević, Bogdan Milićević, Vladimir Simić, Nenad Filipović, Miloš Kojić
A COMPUTATIONAL MODEL DEVELOPED TO DEMONSTRATE THAT DURING THE SPIDER SILK SPINNING INTERNAL DIFFUSION GOVERNS WATER REMOVAL – A PROCESS CENTRAL TO THE GENERATION OF SPIDER SILK’S EXCEPTIONAL MECHANICAL PROPERTIES
Solvent removal by diffusion from a polymer solution occurs in various technological processes, such dry spinning of synthetic silk-like fibers. There, it is important to determine the diffusion coefficient which is dependent on the solvent concentration, assuming the validity of Fick’s law. In order to prove the internal diffusion within the...
By Nikola Kojić, Aleksandar Kojić, Miloš Kojić
USER INTERFACES CAD SOFTWARE FOR PRE- AND POST- PROCESSING OF MODELS ACCOMPANYING PAK FE CODE
This paper introduces the CAD user interface software developed to support example-driven simulations using the PAK finite element code. Built upon years of research and development by the authors, CAD represents a custom-built platform for three-dimensional model setup and result visualization, tightly integrated with the PAK solver. It facilitate...
By Miljan Milošević, Vladimir Simić, Bogdan Milićević, Velibor Isailović, Vladimir Ranković, Miloš Ivanović, Žarko Milošević, Dalibor Nikolić, Danko Milašinović, Arso Vukićević, Lazar Otašević, Mileta Stojanović, Nenad Filipović, Miloš Kojić, Boban Stojanović
OUR MULTISCALE FINITE ELEMENT MODEL OF GROUNDWATER FLOW TO RADIAL WELL
A water supply system with radial wells (RWs) extends usually over tens of kilometers horizontally and tens of meters deep within the soil. Water flows through the soil and then through several lateral screens to the vertical shaft. Lateral screens represent perforated pipes with lengths in meters and diameters measured in centimeters. A common app...
By Vladimir Ranković, Nenad Filipović, Boban Stojanović, Velibor Isailović, Miloš Kojić
NUMERICAL HOMOGENIZATION AS A METHOD FOR MODELING CONSTRAINED DIFFUSION
Material transport by diffusion is present in nature, as well as in living organisms as a vital process. The basic and generally used is a phenomenologically established law, named Fick’s law, It states that the material flux is proportional to the concentration gradient and that the material flows from the higher to lower concentration. Howe...
By Miloš Kojić, Miljan Milošević, Alessandro Grattoni, Mauro Ferrari