The interaction between the Finite Element Method (FEM) and Smoothed Particle Hydrodynamics (SPH) is crucial in multiphysics simulations of granular–structure systems, impacts, and material behavior. This paper presents a penalty-based contact algorithm with Coulomb friction for FEM–SPH coupling. The method accounts for static and dynam...

By Marko Topalović, Miloš Ivanović, Snežana Vulović, Aleksandar Nikolić, Miroslav Živković

In silico clinical trials are set to transform medicine by enabling virtual testing and simulation, which streamline the development of medical devices and pharmaceuticals while reducing costs and duration. The SILICOFCM platform offers a innovative, multi-modular approach designed to optimize overall heart function and monitor the effectiveness of...

By Nenad Filipović, Igor Saveljić, Tijana Geroski, Smiljana Tomašević, Miljan Milošević, Bogdan Milićević, Momčilo Prodanović, Srboljub Mijailović, Miloš Kojić

This paper presents a method for improving the numerical analysis of contact problems using a penalty formulation. Since contact phenomena are inherently nonlinear, particularly in the case of large deformations, an incremental solution strategy is required. Conventional Newton-Raphson algorithms often face convergence problems when many nodes make...

By Snežana Vulović, Miroslav Živković, Nenad Grujović, Marko Topalović

The concrete damaged plasticity (CDP) model is one of the most popular constitutive models implemented into various Finite Element Method software. The application to the real structures is documented in the literature, but still there are some doubts about the response in combination with the various finite elements. Simple benchmark examples simu...

By Vladimir Dunić, Nenad Grujović, Aleksandar Bodić, Dragan Rakić, Miroslav Živković

The paper presents various examples of the application of the PAK software and its modules for thermal, filtration, and stress–strain analysis of different complex engineering structures such as gravity dams, arch dams, embankment dams, tunnels, and mines. Examples of research, studies, and projects in which PAK has been applied to assess the...

By Dejan Divac, Slobodan Radovanović, Maja Pavić, Nikola Milivojević, Vladimir Milivojević, Miroslav Živković, Dragan Rakić, Snežana Vulović

Two-equation turbulent models are widely used in finite element analysis of fluid flow. The PAK program package was upgraded from the classical laminar flow to the turbulent k-omega model. The turbulence model was validated using the case of fluid flow in a backward-facing step channel. The analysis results show good agreement with experimental dat...

By Aleksandar Nikolić, Miroslav Živković, Nenad Filipović, Marko Topalović

This study investigates the drug release performance of electrospun composite nanofiber mats, which hold significant promise as drug carriers for site-specific delivery in therapeutic applications such as cancer therapy. Predicting drug release rates from poly(D,L-lactic-co-glycolic acid) (PLGA) nanofibers produced via emulsion electrospinning is c...

By Miljan Milošević, Vladimir Simić, Bodan Milićević, Dušica Stojanović, Mirjana Grković, Miloš Bjelović, Petar Uskoković, Miloš Kojić

Degradation of structural integrity and fatigue life estimation remain critical challenges in engineering, including biomedical applications. Fracture mechanics and crack propagation prediction are highly sensitive to material parameters, with the Stress Intensity Factor being the most significant physical parameter for the estimation of crack stre...

By Gordana Jovičić, Vladimir Milovanović, Aleksandra Vulović, Miroslav Živković, Nenad Đorđevič, Nenad Filipović

This study presents the use of computational modeling to improve understanding of hypertrophic cardiomyopathy (HCM) and its progression to heart failure. A review of related work highlights advances and challenges in computational modeling and integration of clinical data for model development and validation. Using parametric model of the left hear...

By Smiljana Tomašević, Bogdan Milićević, Miljan Milošević, Nenad Filipović

Understanding the biomechanical response of a femoral bone under physiological loads is critical for assessing bone health and fracture risk, particularly in aging populations affected by osteopenia and osteoporosis. This study investigates the mechanical behavior of the femoral bone under standing loading conditions across three bone states: healt...

By Aleksandra Vulović, Gordana Jovičić, Nenad Filipović