This paper introduces the CAD user interface software developed to support example-driven simulations using the PAK finite element code. Built upon years of research and development by the authors, CAD represents a custom-built platform for three-dimensional model setup and result visualization, tightly integrated with the PAK solver. It facilitate...

By Miljan Milošević, Vladimir Simić, Bogdan Milićević, Velibor Isailović, Vladimir Ranković, Miloš Ivanović, Žarko Milošević, Dalibor Nikolić, Danko Milašinović, Arso Vukićević, Lazar Otašević, Mileta Stojanović, Nenad Filipović, Miloš Kojić, Boban Stojanović

This review summarizes scientific findings from three European Commission FP7 projects. The first, ARTREAT (2008-2013), focused on a multi-level, patient-specific model of artery and atherogenesis for outcome prediction, treatment decision support, and virtual hands-on training. An original method for plaque formation and development was created an...

By Nenad Filipović, Miloš Radović, Tijana Đukić, Igor Saveljić, Bogdan Milićević, Exarchos Themis, Oberdan Parodi, Dimitris Fotiadis

The extremely complex biological and biochemical processes are mainly treated by laboratory and clinical investigations. In recent decades, the application of computational modeling has become more important in research and applications in the medical sciences. Despite enormous efforts and achievements in this modeling, there is still a need for ne...

By Miloš Kojić, Miljan Milošević, Vladimir Simić, Bogdan Milićević

Cardiovascular diseases are among the leading causes of mortality worldwide, necessitating advanced computational modeling to study their underlying mechanisms and explore potential treatments. In this paper, we present a multiphysics computational model that integrates cardiac mechanics, electrophysiology, and mass transport, implemented within th...

By Miljan Milošević, Bogdan Milićević, Vladimir Simić, Nenad Filipović, Miloš Kojić

This study presents the use of computational modeling to improve understanding of hypertrophic cardiomyopathy (HCM) and its progression to heart failure. A review of related work highlights advances and challenges in computational modeling and integration of clinical data for model development and validation. Using parametric model of the left hear...

By Smiljana Tomašević, Bogdan Milićević, Miljan Milošević, Nenad Filipović

In silico clinical trials are set to transform medicine by enabling virtual testing and simulation, which streamline the development of medical devices and pharmaceuticals while reducing costs and duration. The SILICOFCM platform offers a innovative, multi-modular approach designed to optimize overall heart function and monitor the effectiveness of...

By Nenad Filipović, Igor Saveljić, Tijana Geroski, Smiljana Tomašević, Miljan Milošević, Bogdan Milićević, Momčilo Prodanović, Srboljub Mijailović, Miloš Kojić

Huxley-type muscle models offer a physiologically grounded description of cardiac contraction but remain computationally prohibitive for large-scale, multi-scale simulations. This article reviews surrogate modeling strategies that alleviate these costs for ventricular biomechanics, with emphasis on data-driven (RNN/TCN/GRU) and physics-informed (PI...

By Bogdan Milićević, Miloš Ivanović, Boban Stojanović, Miljan Milošević, Miloš Kojić, Nenad Filipović

Heart wall tissue plays a crucial role in living organisms by generating the mechanical force for blood flow. This tissue has a complex internal structure comprised mostly of muscle cells, in which biochemical energy is transformed into mechanical active stress under rhythmical electrical excitation. The overall heart functioning depends, among oth...

By Miloš Kojić, Miljan Milošević, Bogdan Milićević, Vlada Geroski, Vlada Simić, D. Trifunović, G. Stanković, Nenad Filipović